void encrypt(char block[64], int edflag);
#define _XOPEN_SOURCE
#include <stdlib.h>
void setkey(const char *key);
#define _GNU_SOURCE
#include <crypt.h>
void setkey_r(const char *key, struct crypt_data *data);
void encrypt_r(char *block, int edflag, struct crypt_data *data);
Each of these requires linking with -lcrypt.
The encrypt() function modifies the passed buffer, encoding if edflag is 0, and decoding if 1 is being passed. Like the key argument, also block is a bit vector representation of the actual value that is encoded. The result is returned in that same vector.
These two functions are not reentrant, that is, the key data is kept in static storage. The functions setkey_r() and encrypt_r() are the reentrant versions. They use the following structure to hold the key data:
struct crypt_data {
    char     keysched[16 * 8];
    char     sb0[32768];
    char     sb1[32768];
    char     sb2[32768];
    char     sb3[32768];
    char     crypt_3_buf[14];
    char     current_salt[2];
    long int current_saltbits;
    int      direction;
    int      initialized;
};
Before calling setkey_r() set data->initialized to zero.
#define _XOPEN_SOURCE
#include <unistd.h>
#include <stdlib.h>
int
main(void)
{
    char key[64];      /* bit pattern for key */
    char txt[64];      /* bit pattern for messages */
    setkey(key);
    encrypt(txt, 0);   /* encode */
    encrypt(txt, 1);   /* decode */
}